The Department of Chemistry is one of the earliest department to be established at the Nanjil Catholic College of Arts and Science, Kaliyakkavilai, in June 2014 with the introduction of BSc Chemistry. Further in 2015, the department got the affiliation to offer MSc degree programme in Chemistry. The MPhil programme was introduced in the year 2017. The department became the Research Centre in 2018 under Manonmaniam Sundaranar University, Tirunelveli. The department has been engaged in imparting the highest level of quality education in chemistry especially for the girls and rural students.

The department constituted Chemistry Association in 2014. Various guest lectures, workshops, seminars and conferences have been organized under Chemistry Association which has strengthened both the teaching and co-curricular activities of the department. The laboratories are well equipped with a good number of equipment that caters to the requirements of the university syllabus.